Matthew Perry had a ketamine episode days before his death, leaving him unable to move or talk
Days before his death, Matthew Perry had an «adverse medical reaction» to an at-home ketamine injection that left him unable to speak or move, according to federal prosecutors.

Authorities are releasing more details into Matthew Perry’s final days after five people were charged in connection to his death.
The Friends alum was found dead in the hot tub of his Los Angeles home on Oct. 28, with his cause of death later determined to be «acute effects of ketamine» in drug and drowning-related accident.

However, it wasn’t the first time he experienced negative effects of the dissociative anesthetic. Perry had an «adverse medical reaction» to an at-home ketamine injection on Oct. 12,
just 16 days before his death, prosecutors said in unsealed Department of Justice documents reviewed by E! News Aug. 16.

Prosecutors alleged defendant Dr. Salvador Plasencia injected the 54-year-old with «a large dose» of the controlled substance at request of the Perry’s live-in
assistant Kenneth Iwamasa, who has also been charged in the case, after the actor had already undergone ketamine infusion therapy from a doctor’s office.